The Histone Code and Beyond : New Approaches to Cancer Therapy

Language: English

Published by Springer, 2006

3540278575 / 9783540278573

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Seller: AHA-BUCH GmbH, Einbeck, GermanyAHA-BUCH GmbH

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Druck auf Anfrage Neuware - Printed after ordering - Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Seller Inventory # 9783540278573

Title
The Histone Code and Beyond : New Approaches to Cancer Therapy
Author
Bernhard Haendler
Publisher
Springer
Publication year
2006
Condition
Neu
Binding
Buch
Language
English
ISBN 10
3540278575
ISBN 13
9783540278573
Item weight
560 grams
Dimensions
241x160x19 mm

AHA-BUCH GmbH

Einbeck, Germany

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AbeBooks seller since August 14, 2006

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