Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease (eng)

This volume explores various aspects of reversible acetylation of histone and non-histone proteins, focusing on their roles in development, ageing and disease progression.

It examines the biological consequences of modulating acetylation levels by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Covered are manipulations at multiple levels, from in vitro and in vivo studies to clinical trials and FDA-approved therapies. 

The book is divided in four parts:

• Part I provides an overview of post-translational modifications in the context of development, ageing, neurodegenerative and cancer-related diseases. It highlights the role of histone acetylation in higher genome organization and explores the functions of the proteins involved.
• Part II focuses on the modulation of cytoskeleton-associated proteins through reversible acetylation. It examines how acetylation influences cytoskeletal compartments, thereby regulating cellular structure and function.
• Part III examines acetylation in the context of development. It describes acetylation as a key regulator of early embryogenesis, influencing chromatin structure and gene expression.
• Part IV discusses physiological and pathological aspects of histone and non-histone protein acetylation and its modulation by activators and inhibitors.

The book is a valuable resource for scientists, clinicians and academic teachers alike.

Marta Halasa earned her PhD in medical and health science from the Medical University of Lublin, Poland, in 2022. Her research during her doctoral studies focused on epigenetic modifiers, particularly histone deacetylases, and their impact on cancer progression and metastasis. During her PhD, she completed a long-term internship at the University of Turku, Finland, where she gained expertise in 3D cell techniques. She also undertook an internal internship at the Military Institute of Medicine in Warsaw, Poland, where she investigated cell-gene therapy in Alzheimer's disease. After completing her PhD, she obtained a postdoctoral fellow position at the Houston Methodist Research Institute, USA. Currently, her research focuses on investigating the role of macrophages in chronic transplant rejection. 

Anna Wawruszak got her PhD at the Department of Biochemistry and Molecular Biology at the Medical University in Lublin, Poland, in 2020. Since then, she has been working at the Medical University of Lublin as a postdoc, researcher and, finally, an Associate Professor. Her primary expertise lies in translational medicine, epigenetics and breast cancer research. Her work is mainly focused on the anti-cancer activity of histone deacetylase inhibitors in breast cancer models. She has also an interest in green chemistry and biotechnology approaches for the development of nature-based cosmetics.