Homology Modeling of Human NK-1 Receptor and Docking Study: Structure Based Drug Design

Gupta, Manish K., Kumar, Viney

ISBN 10: 3659804207 / ISBN 13: 9783659804205

Published by LAP LAMBERT Academic Publishing, 2015

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Bibliographic Details

• Title: Homology Modeling of Human NK-1 Receptor and Docking Study: Structure Based Drug Design
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2015
• Language: English
• ISBN 10: 3659804207
• ISBN 13: 9783659804205
• Binding: paperback
• Condition: Like New
• Book Type: book

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Synopsis

Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the human NK-1 receptor using multiple templates to provide structural basis for the design of new NK-1 inhibitors and anticancer agents. The authors anticipate that the book will be very useful for the researchers who are working on the design and development of NK-1 receptor antagonists and anticancer agents.

About the Author

Manish Kumar Gupta (M. Pharm., PhD., Postdoc): Professor of Pharmacy, Lloyd Inst. of Mang. & Tech. Gr. Noida, India. His research work focuses on the ligand and structure based drug design, protein modeling and molecular dynamics simulation studies. He has published several research papers in peer-reviewed journals of ACS, Springer and Elsevier.