This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases.
Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease

describes the molecular architecture of the complement system

details the structure of complement genes

discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins

analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway

elucidates the regulation of complement gene expression and the structure and function of bioactive peptides

explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria

and more!

About the Author

John E. Volanakis

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