Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment

David A. Neumann/ Carole A. Kimmel

ISBN 10: 0849328055 / ISBN 13: 9780849328053

Published by Informa HealthCare, 1998

About this Item

1st edition. 272 pages. 10.50x7.50x0.75 inches. In Stock.

Seller Inventory # x-0849328055

Bibliographic Details

• Title: Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment
• Publisher: Informa HealthCare
• Publication Date: 1998
• Language: English
• ISBN 10: 0849328055
• ISBN 13: 9780849328053
• Binding: Hardcover
• Condition: Brand New
• Weight: 0.67 kilograms

About this title

Synopsis

and for those interested in toxic effects of chemicals on humans, Human Variability in Response to Chemical Exposures: Measures, Modeling, and Risk Assessment recognizes and addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to chemicals. Eight original manuscripts, commissioned by the ILSI Risk Science Institute, address the evidence for variability in human response to chemicals associated with reproductive and developmental effects, effects on the nervous system and lungs, and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations. This book recognizes that understanding of variability in response is critical in accounting for interindividual variability in susceptibility and, hence, risk, if the regulatory community and others are expected to characterize human health risks associated with exposure to chemicals. Models for incorporating measures of response variability in the risk assessment process are critically reviewed and illustrated with published data. This authoritative work indicates that, in the case of certain chemicals and in the context of certain specific toxic effects, we have considerable ability to predictively and quantitatively characterize human variability, but, in the majority of cases, our ability to do so is limited. If we improve both quantity and quality of information available on response variability and increase our understanding of target tissue dosimetry, we should be better able to account for variability in human susceptibility to the toxic effects of chemicals.

About the Author

Eckerman, David A.