Title: INTERACTIONS DU SYSTEME NERVEUX CENTRAL ET PERIPHERIQUE: CARACTERISATION PHYSIOPATHOLOGIQUE, MOLECULAIRE ET METABOLIQUE DE LA JONCTION NEUROMUSCULAIRE . CENTRAL (Omn.Univ.Europ.) (French Edition)
Publisher: Editions universitaires europeennes
Publication Date: 2010
Language: French
ISBN 10: 6131511489
ISBN 13: 9786131511486
Binding: Soft cover
Condition: New

About this title

Synopsis

Une l�sion du SNC entraine chez l'homme un handicap fonctionnel majeur. Celui-ci provient � la fois des d�g�ts neuronaux primitifs, mais aussi d'une spasticit� et d'une amyotrophie difficiles � attribuer � une simple sous-utilisation musculaire. Ce travail a permis d'incriminer des dysfonctionnements morphologiques et m�taboliques pr�coces survenant dans les nerfs p�riph�riques et muscles sous-jacents � une l�sion du SNC. Il sugg�re d'une part l'existence d'une circuiterie intra-spinale et d'autre part le r�le potentiel de signalisation intracellulaire neuronal des isoformes de la pompe � sodium. Nous avons �galement observ� des modifications pr�coces du m�tabolisme �nerg�tique lipidique impliquant particuli�rement les acides gras poly-insatur�s, dont la participation serait directement au c?ur des m�canismes de r�paration neuronale. Les perspectives de recherche qui en d�coulent pourraient nous amener � �largir notre approche m�tabolique � un regard r�solument tourn� vers la fonction et la programmation motrice. De telles ambitions restent � la hauteur du challenge laiss� quasiment intact par ces travaux de nature exploratoire.

About the Author

Philippe RIGOARD, praticien hospitalier en Neurochirurgie au CHU de Poitiers, Attach� d'enseignement au Laboratoire d'Anatomie, Facult� de M�decine de Poitiers, Docteur en Physiologie et communications intercellulaires. Chirurgie du rachis, de la moelle �pini�re et des nerfs p�riph�riques, chirurgie de la douleur et de la spasticit�.

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