Immobilizable Bisubstrate-Analogue Inhibitors Of Protein Kinases: Development And Application In Surface Plasmon Resonance Biosensors

Viht, Kaido; Viht, Kaido

ISBN 10: 3639189221 / ISBN 13: 9783639189223

Published by Vdm Verlag Dr. Müller, 2009

About this Item

52 pages. 8.66x5.91x0.12 inches. In Stock.

Seller Inventory # __3639189221

Bibliographic Details

• Title: Immobilizable Bisubstrate-Analogue Inhibitors Of Protein Kinases: Development And Application In Surface Plasmon Resonance Biosensors
• Publisher: Vdm Verlag Dr. Müller
• Publication Date: 2009
• Language: English
• ISBN 10: 3639189221
• ISBN 13: 9783639189223
• Binding: Paperback
• Condition: Brand New
• Weight: 0.13 kilograms

About this title

Synopsis

During the recent 10 years, protein kinases (PKs) have become one of the most important drug targets. An increasing number of inhibitors of PKs have entered clinical trials, mostly for the treatment of several forms of cancer. In parallel with the development of inhibitors of PKs as potential drug candidates, new bioanalytical methods for their evaluation are elaborated. The Group of Medicinal Chemistry at the University of Tartu, Estonia has developed adenosine-oligoarginine conjugates (ARCs), bisubstrate-analogue inhibitors of PKs. This book presents a doctoral thesis on the development of immobilizable ARCs and their application in surface plasmon resonance (SPR) biosensors. An introductory part of the thesis gives an overview on cyclic adenosine monophosphate (cAMP)-dependent PK, PK assays, polymer-supported organic synthesis, polymer therapeutics, and ARCs. An experimental part reviews three research papers that describe a new fluorescence-based assay for cAMP-dependent PK, polymer-supported synthesis and cellular uptake of pegylated ARCs, and the application of ARCs in SPR biosensors. This book should be interesting to scientists working with PKs and bioanalytical methods.

About the Author

Kaido Viht was born in Tallinn, Estonia. He studied chemistry in the University of Tartu and received his PhD in Bioorganic Chemistry in 2007. Currently he is working as research scientist in the University of Tartu, Estonia.