Immunogenicity of Biopharmaceuticals

Marco Weert

ISBN 10: 0387758402 / ISBN 13: 9780387758404

Published by Springer, 2008

About this Item

Druck auf Anfrage Neuware - Printed after ordering - A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho's blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies.This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.

Seller Inventory # 9780387758404

Bibliographic Details

• Title: Immunogenicity of Biopharmaceuticals
• Publisher: Springer
• Publication Date: 2008
• Language: English
• ISBN 10: 0387758402
• ISBN 13: 9780387758404
• Binding: Buch
• Condition: Neu
• Dimensions: 260W x 183H x 22D millimeters 260 millimeters width by 183 millimeters height by 22 millimeters depth
• Weight: 792 grams

About this title

Synopsis

A particular issue for biopharmaceuticals that has not been addressed comprehensively in any book, is the potential of an immune response to the biopharmaceutical product. That is, the human body marks the drug as a foreign body, and develops antibodies against the drug. These antibodies may be relatively harmless, but may also cross-react with the endogenous compound, causing autoimmunogenicity. Recent adverse experiences in Europe with Janssen-Ortho’s blockbuster product Eprex has increased the attention towards potential immunogenicity of biopharmaceuticals, above all from the regulatory agencies.

This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.