Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology

Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology covers the major mechanisms and effects of toxic substances on the immune system, and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, and emerging and future trends. The book begins with a discussion of the systemic approach to toxicants, but also looks at current genomic tools used to assess immunotoxicity and systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data.

This book provides a collaborative, multidisciplinary approach for researchers in the fields of toxicology, genetics, immunology, and others engaged in the study on the effects of toxic substances on immune responses.

• Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects
• Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression
• Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives

Md. Niamat Ali, MPhil, PhD is Director and Professor at the Centre of Research for Development at the University of Kashmir, Srinagar, India. After completing his doctorate in Zoology (Specialization in Cytogenetics and Molecular Biology) at Aligarh Muslim University, he worked there as a Research Associate. He later joined the Department of Zoology at the University of Kashmir. Prof. Ali has more than 29 years of research experience and 25 years of teaching experience in Cytogenetics and Molecular Biology, Toxicogenomics, Human Genomics and Proteomics, Stem Cell Biology, Regenerative Medicine, Radiation Biology and Gene Therapy, Cell and Tissue Culture Technology among other topics. He is a Life Member of Indian Science Congress Association and Environmental Mutagen Society of India. He has authored numerous publications in peer-reviewed journals and multiple book chapters in edited volumes with international publishers. He serves on the editorial board and as a reviewer for several high-impact international scientific journals.

Shafat Ali (Ph.D.) pursued his BSc. from University of Kashmir and Masters in Zoology from Barkatullah Vishwavidyalaya, India. Currently he is engaged in research work in the Department of Zoology and previously in the Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development at the University of Kashmir, Department of Biochemistry, Government Medical College, Srinagar, Jammu and Kashmir, and ICMR funded Multidisciplinary Research Unit, Government Medical College, Srinagar, Jammu and Kashmir, India, with specialization in the field of reproductive immunogenetics, cytokine biology, gynaecology and obstetrics, molecular biology, cancer biology and cytogenetics. He has 5 years of research experience and 5 years of teaching experience. He has more than 20 book chapters, several edited books and numerous peer-reviewed, international research publications to his credit. Dr. Ali is also the reviewer of many reputed international journals. Presently, Dr. Ali is involved in studying immunogenetic mechanisms involved in recurrent pregnancy loss.

Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.