Impact of Folate Absorption and Transport for Nutrition and Drug Targeting

N. Ceren Alemdaroglu

ISBN 10: 363901068X / ISBN 13: 9783639010688

Published by VDM Verlag Dr. M�ller 2008-04-25, 2008

About this Item

Seller Inventory # 6666-IUK-9783639010688

Bibliographic Details

• Title: Impact of Folate Absorption and Transport for Nutrition and Drug Targeting
• Publisher: VDM Verlag Dr. M�ller 2008-04-25
• Publication Date: 2008
• Language: English
• ISBN 10: 363901068X
• ISBN 13: 9783639010688
• Binding: Paperback
• Condition: New

About this title

Synopsis

Food-drug interactions play an important role in the alteration of the pharmacokinetics as well as pharmacodynamics of drugs in vivo. The interaction of folic acid and tea was observed at the level of cellular uptake using Caco-2 cell monolayers. Remarkably, the clinical study with healthy human volunteers confirmed the interaction between tea and folic acid in vivo leading to lower bioavailabilities of folic acid. This outcome addresses the clinical consequences of folate deficiency caused by high intakes of tea. Folates have been employed as targeting moieties to tumor cells. Folic acid has a high affinity to folate receptors which are overexpressed in tumor cells. Therefore internalization of folic acid conjugated drugs or drug delivery systems are readily carried out via those receptors. A novel micelle platform consisting of amphiphilic DNA block copolymers was introduced for the first time for chemotherapeutic drug delivery, allowing the combinatorial testing of the drug carrier system. Folic acid conjugated nanoparticles act as a potential chemotherapeutic drug delivery system in in vitro assays.

About the Author

The author was born in Ankara, 1979; obtained BS & MS degrees from Gazi University, School of Pharmacy; specialization in the field of Pharmaceutical Technology; awarded a DAAD scholarship and completed her PhD at the University of Mainz in the Institute of Pharmaceutical Technology&Biopharmacy.Currently, a scientist at the University of Münster.