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ABEL, John J.; Rowntree, Leonard G.; and Turner, B. B. 3 Important Papers. (1) "On the removal of diffusible substances from the circulating blood of living animals by dialysis" (1914). OFFERED WITH: (2) "On the removal of diffusible substances from the circulating blood of living animals by dialysis. II. Some Constituents of the Blood " (1914) AND WITH: (3) "Plasma Removal with Return of Corpuscles (Plasmaphaeresis), First Paper." All OFFPRINTS from Journal of Pharmacology and Experimental Therapeutics. Abel, John Jacob (1857-1938); Rowntree, Leonard G.; and Turner, B. B. The three papers that follow are all offprints from Journal of Pharmacology and Experimental Therapeutics, printed at the Waverly Press, Baltimore. (1) "On the removal of diffusible substances from the circulating blood of living animals by dialysis" volume 5, no. 3, January 1914, printed at the Waverly Press, Baltimore, pp 275-316pp, with illustrations in text. (2) "On the removal of diffusible substances from the circulating blood of living animals by dialysis. II. Some Constitu-ents of the Blood " (1914), Vol 5 no. 6, July 1914, pp 611-623. VG-Fine. Mostly unopened. (3) "Plasma Removal with Return of Corpus-cles (Plasmaphaeresis), First Paper" vol 5 no 6 pp 624-641, mostly unopened. [++] "Plasmapheresis is derived from a Greek word meaning to take away by force. The term was first used by Abel in 1914 in his report entitled, Plasma removal with return of corpuscles (plasmapheresis) [one of the papers offered here] wherein he reported that large amounts of plasma could be collected from an animal if the red blood cells were returned. It is only within the past twenty-five years that this term has come into prominence. Today, plasmapheresis is the separation of plasma from the cellular components of blood with the cells being returned to the patient. The primary use of this procedure is in the collection of normal plasma for fractionation."--Helen E. Kambic and Yukihiko Nose, "Historical Perspective on Plasmapheresis" in Therapeutic Apheresis 1(1):83-108, 1997.[++] In 1912 and the years immediately following, Abel became deeply interested in work with the protein constituents of the blood. He suggest-ed in 1912 that an artificial kidney might be utilized in the removal and study of diffusible substances of the blood. An apparatus of coiled collodion tubes surrounded by a saline solution was soon devised and used for this purpose; arterial blood was shunted through these tubes and then returned to the experimental animal s vein. Using this technique, Abel succeeded in demonstrating the existence of free amino ac-ids in the blood. Even at this time (1913), Abel seems to have been aware of the clinical potential of what he called his vividiffusion appa-ratus; it might, he suggested, prove useful in managing renal failure. A second and related aspect was Abel s demonstration that large quanti-ties of blood could be removed from the circulation if the washed and centrifuged corpuscles were returned. Abel also showed remarkable foresight in his suggestion that plasmaphaeresis his term for this procedure might ultimately be used to create blood banks for use in traumatic and surgical emergencies. Complete DSB online. [++] The first plasmapheresis procedure was performed by Abel, Rowntree, and Turner on dogs following bilateral nephrectomy. They separated blood components, removed the plasma, and returned the red blood cells (suspended in a solution) to the animals. This resulted in a marked improvement in the treated animals. Wikipedia [++] "John Abel's research group from Baltimore is widely known around the world. One can read a lot in almost every manual or textbook on dialysis or plasmapheresis. But the precedence of Russian scientists in this field as well as their contributions to the development of the field is much less known for unfortunate reasons."--Alexey A Sokolov, Andrey G Solovyev. Russian Pioneers of Therapeutic Hem.
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