Inhaled Steroids in Asthma: Optimizing Effects in the Airways (Lung Biology in Health and Disease)

This book sums up the mechanistic basis, current status, and future prospects of steroid inhalation as the cornerstone of prophylactic asthma therapy, identifying its kinetic basis-especially the essential airway selectivity-and including a historical account of inhaled glucocorticoid development.
Makes connections among the underlying pharmacology, impact of new simulation models, newly recognized molecular targets, and therapeutic outcomes of short- and long-term steroid inhalation therapy!
Containing more than 1600 works cited, drawings, tables, equations, and micrographs, Inhaled Steroids in Asthma

describes the developmental history of inhaled steroids and provides general models for lung selectivity

considers the best way to select inhaled steroids

clarifies local metabolism, airway and lung uptake and retention, and other determinants of once-daily usage

addresses variations in lung deposition and total bioavailability among available steroids and formulations

surveys the dynamics of receptor gene-mediated processes

analyzes the role of chemokines in airway allergic inflammatory diseases

discusses the effects of inhaled steroids in vivo on cell progenitors in asthma and rhinitis

details measuring airway inflammation as a guide for treatment decisions

outlines the clinical relevancy of exhaled nitric oxide in asthma

covers optimal trial design for judging antiasthmatic potency and efficacy

evaluates the safety of inhaled steroids
Written by more than 40 of the world's leading authorities and investigators, Inhaled Steroids in Asthma is an authoritative reference for pulmonologists and pulmonary disease specialists; physiologists; allergists; immunologists; molecular, cell, and lung biologists; pediatricians; pharmaceutical scientists and pharmacologists; and medical school and upper-level undergraduate, graduate, and medical school students in these disciplines.

Robert P. Schleimer The Johns Hopkins University School of Medicine and The Johns Hopkins Asthma & Allergy Center Baltimore, Maryland Paul M. O’Byrne McMaster University and St. Joseph’s Hospital Hamilton, Ontario, Canada Stanley J. Szefler University of Colorado Health Sciences Center and National Jewish Medical and Research Center Denver, Colorado Ralph Brattsand AstraZeneca Research and Development Lund, Sweden.