Inhibitor designing of mycolic acid precursor RmlA of M. Tuberculosis

Mansuri, Rani, Sahoo, Ganesh Chandra, Das, Pradeep

ISBN 10: 3330052724 / ISBN 13: 9783330052727

Published by LAP LAMBERT Academic Publishing, 2017

About this Item

NEW. SHIPS FROM MULTIPLE LOCATIONS.

Seller Inventory # ERICA82933300527246

Bibliographic Details

• Title: Inhibitor designing of mycolic acid precursor RmlA of M. Tuberculosis
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2017
• Language: English
• ISBN 10: 3330052724
• ISBN 13: 9783330052727
• Binding: paperback
• Condition: New
• Book Type: book

About this title

Synopsis

This book consist of development of Mycobacterium tuberculosis inhibitors through insilico approach such as design of side chain analogues through combinatorial approach. The designed analogues have good ADMET properties and Lipinski's drug like criterion and may be used as newer candidate for Tuberculosis. Apart from development of analogues the 3D model of RmlA protein responsible for the formation of mycolic acid was built and various designed analogues were screened through it, that yielded few potential inhibitors against RmlA.

About the Author

Dr. Rani Mansuri has completed her M.S. and PhD. from NIPER,Hajipur and RMRI,PATNA, India. She is expertise in various Insilico work such as database designing and programming, Docking and Virtual screenin, molecular dynamics simulation Protein expression, enzymatic assay, Cell culture etc. Many years she has worked on Tuberculosis and kalaazar.