Insilico Docking Against Breast Cancer using Rhinacanthone: Insilico Docking Analysis of Rhinacanthus Nasutus Derived Compound against Breast Cancer Using Bioinformatics softwares

Radhamahendran, S., Udaybhaskar, P., Ramkumar, A.

ISBN 10: 3659185507 / ISBN 13: 9783659185502

Published by LAP LAMBERT Academic Publishing, 2012

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Bibliographic Details

• Title: Insilico Docking Against Breast Cancer using Rhinacanthone: Insilico Docking Analysis of Rhinacanthus Nasutus Derived Compound against Breast Cancer Using Bioinformatics softwares
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3659185507
• ISBN 13: 9783659185502
• Binding: Paperback
• Condition: Like New
• Book Type: book

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Synopsis

The drug-likeness and efficiency of various herbal compounds were screened by docking studies. One of the main pharmacological problems today in the treatment of cancer consists of the fact that anti-inflammatory drugs usually exhibit side effects. The natural products offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Computer-aided drug design has proved to be a very useful tool for discovering new drugs. Rhinacanthus nasutus is an important medicinal plant which possess bioactive compound “Rhinacanthone”In this work an attempt was made to dock the target proteins of breast cancer with rhinacanthone and the plant genome was annotated using various bioinformatics software tools to decipher the biological functions of various proteins present in it.Rhinacanthone was found to have best interaction with BRCA1 target protein. Thus this small molecule Rhinacanthone is suggested to be used clinically as anti tumor agent.

About the Author

Ms.RadhaMahendran,M.Sc.,M.tech.,(PhD),AssistantProfessor & HOD,Department of Bioinformatics,VelsUniversity,Chennai,India.Her major area of research includes Molecularbiology /Genetics/ Structural-bioinformatics/ molecularmodelling and computer aided drug designing.she has published articles in reputed journals.