Insilico Docking Against Breast Cancer using Rhinacanthone | Insilico Docking Analysis of Rhinacanthus Nasutus Derived Compound against Breast Cancer Using Bioinformatics softwares | S. Radhamahendran (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659185502 | Verantwortliche Person f�r die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabr�ck, mail[at]preigu[dot]de | Anbieter: preigu.

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Title

Insilico Docking Against Breast Cancer using Rhinacanthone | Insilico Docking Analysis of Rhinacanthus Nasutus Derived Compound against Breast Cancer Using Bioinformatics softwares

Publisher

LAP Lambert Academic Publishing

Publication Date

2012

Language

English

ISBN 10

3659185507

ISBN 13

9783659185502

Binding

Taschenbuch

Condition

Neu

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B�cher

About this title

Synopsis

The drug-likeness and efficiency of various herbal compounds were screened by docking studies. One of the main pharmacological problems today in the treatment of cancer consists of the fact that anti-inflammatory drugs usually exhibit side effects. The natural products offer a great hope in the identification of bioactive lead compounds and their development into drugs for treating inflammatory diseases. Computer-aided drug design has proved to be a very useful tool for discovering new drugs. Rhinacanthus nasutus is an important medicinal plant which possess bioactive compound “Rhinacanthone”In this work an attempt was made to dock the target proteins of breast cancer with rhinacanthone and the plant genome was annotated using various bioinformatics software tools to decipher the biological functions of various proteins present in it.Rhinacanthone was found to have best interaction with BRCA1 target protein. Thus this small molecule Rhinacanthone is suggested to be used clinically as anti tumor agent.

About the Author

Ms.RadhaMahendran,M.Sc.,M.tech.,(PhD),AssistantProfessor & HOD,Department of Bioinformatics,VelsUniversity,Chennai,India.Her major area of research includes Molecularbiology /Genetics/ Structural-bioinformatics/ molecularmodelling and computer aided drug designing.she has published articles in reputed journals.

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