Integrative Structural Biology with Hybrid Methods

Haruki Nakamura

ISBN 10: 981132199X / ISBN 13: 9789811321993

Published by Springer, Springer, 2019

About this Item

Druck auf Anfrage Neuware - Printed after ordering - This book presentsa newemergingconcept of 'Integrative Structural Biology'. It coverscurrent trends of the molecular and cellular structural biology,providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understandthe hybrid methods. This bookdiscusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion ofthe data validation and archive, which are big problems in this filed along with the progress of this field. Theresearchersin biology will be interested inthis book as a guide book for learning the current structure biology, but also those instructure biologymay use this book as a comprehensive reference to cover broad topics.

Seller Inventory # 9789811321993

Bibliographic Details

• Title: Integrative Structural Biology with Hybrid Methods
• Publisher: Springer, Springer
• Publication Date: 2019
• Language: English
• ISBN 10: 981132199X
• ISBN 13: 9789811321993
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 160H x 20D millimeters 241 millimeters width by 160 millimeters height by 20 millimeters depth
• Weight: 639 grams

About this title

Synopsis

This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested inthis book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.

About the Author

Haruki Nakamura

Osaka University, Institute for Protein Research, Japan

Gerard J. Kleywegt

European Bioinformat Inst, Prot Data Bank Europe, England

Stephen K. Burley

Rutgers State University, Center for Integrative Proteomics Research, USA

John L. Markley 

University of Wisconsin, Biochemistry Department, Natl Magnet Resonance Facil Madison, USA