Interplay between DNA replication and repair | The proposed model for replication restart

Razieh Pourahmad Jaktaji

ISBN 10: 384733901X / ISBN 13: 9783847339014

Published by LAP Lambert Academic Publishing, 2012

About this Item

Interplay between DNA replication and repair | The proposed model for replication restart | Razieh Pourahmad Jaktaji | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783847339014 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 106649027

Bibliographic Details

• Title: Interplay between DNA replication and repair | The proposed model for replication restart
• Publisher: LAP Lambert Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 384733901X
• ISBN 13: 9783847339014
• Binding: Taschenbuch
• Condition: Neu
• Seller catalogs:
  • Bücher

About this title

Synopsis

DNA replication complexes assembled at origins of replication are intrinsically highly processive. However, their progression is often hindered by lesions in or on the DNA. There is growing evidence that RNA polymerase stalled itself at a lesion in the template strand is a major obstacle, especially in UV-irradiated cells. The data presented in this book provide information and propose model on how modulation of RNA polymerase activity might enable UV-irradiated cells lacking RuvABC to overcome obstacles caused by the stalling of RNA polymerases at UV-induced DNA lesions. The proposed model for replication restart relies on PriA protein, but does not require RecBCD and thus does not proceed via recombination and Holliday junction resolution or even via processing of a DNA end by RecBCD. However, it does require the UvrABC excision repair pathway and RecG protein. The book describes studies indicating that in rpo* cells, replication forks may run directly into lesions in DNA rather than into RNA polymerase stalled at lesions, and that this leads to direct fork rescue without recombination with the aid of SOS induction, which increases excision repair to remove lesions at other sites.

About the Author

Dr. Razieh Pourahmad Jaktaji has obtained her Ph D degree in Genetics in 2002. Since then she has worked in Shahrekord University. She is the author and co-author of several papers published in reputed journals.