Contents I. Scope of bioinformatics biological data and internet basics 1. Information flow in biology. 2. DNA sequence data. 3. Experimental approach to genome sequencing. 4. Genome information resources. 5. Protein sequence and structural data. 6. Internet basics. II. Sequence databases 7. Biological data analysis and applications. 8. Sequence databases. 9. NCBI model. 10. File formats. 11. Secondary databases. III. Sequence alignment and database search 12. Protein primary sequence analysis. 13. DNA sequence analysis. 14. Pair wise sequence alignment. 15. FASTA algorithm. 16. BLAST algorithm. 17. Multiple sequence alignment. 18. Database searching using BLAST and FASTA. IV. Structural databases 19. Small molecule databases. 20. Protein information resource. 21. Protein databank. 22. SCOP and CATH. V. Introduction to molecular modelling chemoinformatics and analog based drug designing 23. Modelling 3D structures of small molecules. 24. Modelling biopolymers DNA and oligopeptides. 25. Chemoinformatics and quantum chemical methods. 26. Introduction to QSAR. VI. Basic principles of protein modelling and rational drug designing 27. Secondary structure prediction of proteins. 28. Homology based modelling of a protein. 29. Introduction to target structure based drug design. Index. Bioinformatics is an integral part of development and design of new products and processes in biotechnology R&D in pharma sector contract research outsourcing (CRO) drug trials medical informatics etc. However there is a great need of manpower to develop algorithms and software design databases manage gene banks protein banks and banks for biochemical reactions to analyse biochemical and 3D structural databases to create mirror sites and project oriented links to study genomics proteomics protein modelling and drug designing. This needs inputs from various disciplines as mathematics physics chemistry statistics computer science information technology biochemistry biotechnology pharmacology and medical sciences. A new entrant into this subject may get lost at From where to begin. What should be his or her objective. Many words like chemoinformatics drug designing and protein engineering are beyond his or her comprehension. What he or she needs at this juncture is an introduction do different areas in bioinformatics in a way which is easily understandable. The book is written in keeping with the school level knowledge in physics chemistry mathematics and biology. However the student is expected to be a computer literature in order to practice experiments suggested at the end of this book. 312 pp.

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Bibliographic Details

Title

Introduction to Bioinformatics

Publisher

Duckworth Press

Publication Date

2007

Language

English

ISBN 10

8190469908

ISBN 13

9788190469906

Binding

Soft cover

Condition

As New

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