Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics

Gary D Stormo

ISBN 10: 1936113503 / ISBN 13: 9781936113507

Published by Cold Spring Harbor Laboratory Press,U.S., 2013

About this Item

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Bibliographic Details

• Title: Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics
• Publisher: Cold Spring Harbor Laboratory Press,U.S.
• Publication Date: 2013
• Language: English
• ISBN 10: 1936113503
• ISBN 13: 9781936113507
• Binding: Paperback / softback
• Condition: New
• Weight: 416 grams

About this title

Synopsis

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.

About the Author

Gary D. Stormo, PhD, the Joseph Erlanger Professor in the Department of Genetics and Center for Genome Sciences and Systems Biology at Washington University School of Medicine.