Title: Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics
Publisher: Cold Spring Harbor Laboratory Press
Publication Date: 2013
Language: English
ISBN 10: 1936113503
ISBN 13: 9781936113507
Binding: Paperback
Condition: Very Good
Dust Jacket Condition: No Jacket
Weight: 0.8 pounds

About this title

Synopsis

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.

About the Author

Gary D. Stormo, PhD, the Joseph Erlanger Professor in the Department of Genetics and Center for Genome Sciences and Systems Biology at Washington University School of Medicine.

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