An Introduction to the Regulation of Primary Metabolic Pathways [Hardcover]

Language: English. ABOUT THE BOOK: Students who are in undergraduate programs either 3 year or 4 year programs or studying in 5 year integrated Post graduate programs in different disciplines, find it very difficult to get an over view / basics of metabolic regulation and in fact find it daunting to know all the details going through bulky text books. There are also students pursuing UG and PG programs in Engineering & Technology discipline related to Biotechnology. These students are not in need of exhaustive details but only the core details. In addition to students studying in regular mode in India there are many UG and PG programs in life sciences offered in a distance education mode also called correspondence courses. India has many distance education centers both in India and abroad which is likely to be further expanded. Further students appearing for oral interviews for advanced studies both within the country and by telephone/skype from foreign countries need the core concepts rather than exhaustive details. In particular this text would be highly useful for such students. ABOUT THE AUTHOR: Professor A. S. Rao, has a PhD in Biochemistry from Haryana Agricultural University and served the same university for six years. Subsequently joined Bharathidasan University in 1989 and became Professor in 1999 and retired in 2011. During this period served as Syndicate member, Head of the Department of Biotechnology, and Chair, School of Life sciences. Subsequently appointed as Honorary Professor for two years. Has nearly three decades of teaching experience, handling several courses in the broad field of Biochemistry and Biotechnologyfor students from different backgrounds in Life sciences at Undergraduate and Post Graduate level. Further took special interest in Theoretical Biology and policy matters. My interactions at different institutes at Switzerland, U.K, France, Germany, Netherlands, and Singapore have enlightened me about pedagogy, research and policy matters Cumulatively author has about 75 papers in all the above areas in International and National Journals. Policy papers have been published in a Book form along with Professor P. Tauro entitledThoughts on Higher Education. CONTENTS: Acknowledgements . 11 Preface . 13 Foreword . 17 Glossary . 19 PART I BASIC CONCEPTS/TYPES OF METABOLIC REGULATION INVOLVED IN THE REGULATION OF ENZYME ACTIVITY/AMOUNTS 1. An Outline of Various Types of Metabolic Regulation. 47 Changes in substrate/metabolites concentration Changes in pH Reversible covalent modifications of enzymes/nonenzymatic proteins Interconversion of dithiol (2SH) and disulfide (SS) Zymogen activation Oligomerisation status Regulation by compartmentalisation Regulation by isoenzymes Concept of futile/substrate cycles and Reciprocal regulation Metabolism is interconnected Regulation by cell signaling Metabolic control analysis (MCA). PART II REGULATION OF PATHWAYS IN CARBOHYDRATE METABOLISM 2. Glycolysis . 57 General Introduction Regulation. 3. Gluconeogenesis . 65 General Introduction Gluconeogenic reactions Bypassing the irreversible steps in glycolysis Regulatory details of gluconeogenic enzymes. 4. Tricarboxylic acid/Citric acid/Krebs Cycle (Referred in the following discussion as TCA cycle) . 69 General Introduction Regulatory details of different enzymes Energy productionEnergy production in the TCA cycle occurs in several forms GTP Succinyl CoA synthetase catalyzes the reaction Amphibolic nature and interrelationships with biosynthetic pathways of other metabolites. 5. Glyoxylate Cycle and its Regulation . 77 6. Oxidative Pentose Phosphate (OPP) Pathway . 81 General Introduction and functions Pathway reactions and Regulatory details. 7. Regulation of Glycogen Degradation and Biosynthesis . 85 General Introduction Glycogen biosynthesis Glycogen degradation Regulation. PART III REGULATION OF LIPID METABOLISM 8. Triacylglycerol and Fatty Acid Break down .…