Introduction to Statistical Methods for Clinical Trials

Thomas D Cook

ISBN 10: 1584880279 / ISBN 13: 9781584880271

Published by CRC Press Nov 2007, 2007

About this Item

Neuware - This text provides a solid understanding of the various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. It covers basic experimental design, sample size, randomization procedures, interim and survival analyses, quality of life assessment, and longitudinal methods. The book describes all phases of a clinical trial and explores the advantages of and objections to the intent-to-treat principle as well as its implementation. With exercises at the end of most chapters, it also illustrates methods using examples with real data from a variety of disease areas, including heart and lung diseases, cancer, and AIDS.

Seller Inventory # 9781584880271

Bibliographic Details

• Title: Introduction to Statistical Methods for Clinical Trials
• Publisher: CRC Press Nov 2007
• Publication Date: 2007
• Language: English
• ISBN 10: 1584880279
• ISBN 13: 9781584880271
• Binding: Buch
• Condition: Neu
• Dimensions: 241W x 159H x 32D millimeters 241 millimeters width by 159 millimeters height by 32 millimeters depth
• Weight: 844 grams

About this title

Synopsis

Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial.

After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals.

Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.

About the Author

Thomas D. Cook, David L. DeMets