This volume deals with the regulation of ions in brain, and the effects of changing ion levels on the excitability of neurons and on synaptic transmission. The roles of ions in generating epileptic seizures are considered, as well as in the devastation caused by hypoxia and stroke in brain tissue. Num Pages: 504 pages, 8 halftones, numerous line figures. BIC Classification: MJN; PSAN; PSB. Category: (P) Professional & Vocational. Dimension: 243 x 163 x 30. Weight in Grams: 832. . 2004. Illustrated. hardcover. . . . . Books ship from the US and Ireland.

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Bibliographic Details

Title: Ions in the Brain: Normal Function, Seizures, and Stroke
Publisher: OUP USA
Publication Date: 2004
Language: English
ISBN 10: 0195151712
ISBN 13: 9780195151718
Binding: Hardcover
Condition: New

About this title

Synopsis

Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effected by the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.

About the Author

George C. Somjen is at Duke University Medical Center.

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