Isolated Pyranones: Multifaceted Building Blocks for Molecular Diversity covers the latest findings on synthesis and chemical reactivity of highly functionalized pyran-2-ones and pyran-4-ones, their reduced analogs and compounds derived from them through chemical reactions, and their applications in drug discovery and material sciences. It covers the mechanisms of the reaction and step by step formation of final products. Numerous pyranones from natural and synthetic origins, as well as their derived products, have shown diverse pharmacological activities and some are in clinical use. The applications of these compounds are not limited to drug development and imaging agents, and they are also used in material science as organic semiconductors, liquid crystals, organic light emitting diodes (OLEDs), organic catalysts, solid state lasers, photovoltaic and photoconductive devices. The book is ideal for organic, bioorganic, physical, material and natural product chemists working to generate diverse molecular entities through ring transformation reactions of pyranones, and those working in material science to generate new chemical entities.
- Includes various synthetic methodologies for generating molecular diversity
- Covers the applications of functionalized pyranones as substrates for generating new molecular entities such as arenes, heteroarenes, oligoarenes, spiroarenes, and condensed-oligoarenes through base-induced ring transformation, substitution-cyclization and cycloaddition reactions
- Discusses numerous compounds derived from pyranones that are useful as organic semiconductors, liquid crystals, organic catalysts, organic light emitting diodes (OLEDs), solid state lasers, photovoltaic and photoconductive devices
Further to his superannuation as Dy. Director for the Central Drug Research Institute, Lucknow, UP, India, a world class, premier research Institute for drug development, Prof Ram became Emeritus professor and served various academic institutions for 10 years. Besides research experience, he has also earned 18 years of experience teaching heterocyclic chemistry to graduate and post-graduate classes. He has 256 publications to his name, including several review articles published in top chemistry journals. He is also recipient of prestigious fellowships from JSPS, Japan, Alexander von Humboldt (AvH), Germany and NIH, USA.
Prof. Ramendra Pratap completed his master’s from the University of Gorakhpur in 2001 and then he moved to Central Drug Research Institute, Lucknow for doctoral research. He worked with Dr. Vishnu Ji Ram for four and a half years on ring transformation reactions of 2H-pyran-2-ones. He worked on nucleoside modification chemistry as a postdoctoral fellow at the City University of New York, USA, for two years. He received a renowned Humboldt fellowship and shifted to the University of Saarland, Germany. In Saarbrucken, he was involved in Mo-catalyzed reactions. In September 2010, He joined the Department of Chemistry, University of Delhi as an Assistant Professor. Currently, He is working as a full Professor. Till now he has published more than 100 research papers in various international Journals. He also received JSPS invitation fellowship during the year 2016-17. His chemistry focuses on developing various heterocycles, carbocycles, materials, and metal-catalyzed bond formation reactions. His major research contribution involves use of isolated and fused pyranones to establish new molecular entities.
