JAK-STAT Signalling

Language: English

Published by Humana Jan 2013, 2013

162703241X / 9781627032414

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This item is printed on demand - Print on Demand Titel. Neuware -The receptor-associated JAK protein kinases and their substrates, the STAT transcriptional activators, transmit signals following cytokine and growth factor binding to receptors expressed on the cell surface, to result in specific transcriptional and cellular responses.Over the last two decades, the field has progressed from identification of the individual components through to an understanding of the activation and deactivation mechanisms, and the complex structural detail of the proteins involved. We now know that these pathways are important in many biological processes, including growth and development, hematopoiesis, and the innate and adaptive immune response.JAK-STAT Signalling: Methods and Protocolsprovides detailed methodologies for examining many aspects of the pathway. Divided into four sections, topics include JAK and STAT specific approaches, the negative regulators of the pathway (SOCS proteins), and the production and crystallization of JAK and STAT proteins, among others.Written in the successfulMethods in Molecular Biology¿series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.Authoritative and easily accessible,JAK-STAT Signalling: Methods and Protocolswill be of use not only to those working in the area but also to new investigators who are led to delve into the complexities of JAK and STAT responses.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 332 pp. Englisch.

Seller Inventory # 9781627032414

Title
JAK-STAT Signalling
Author
Sandra E. Nicholson
Publisher
Humana Jan 2013
Publication year
2013
Condition
Neu
Binding
Buch
Language
English
ISBN 10
162703241X
ISBN 13
9781627032414
Item weight
823 grams
Dimensions
260x183x23 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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