Kinetics Studies of Reactions at Solid-Liquid Interface: Simulation of Calcification

Calcification is the process in which the mineral calcium (mainly calcium phosphate and calcium oxalate) forms from biological matrices. Many medical problems are also associated with normal and pathological calcifications, like optic calcification of intraocular lens, and kidney stone formation of calcium oxalate concretions having CaP nidi. This book looks at the physico-chemical mechanisms of these processes on both kinetic and molecular levels and applies these theories to show how physiological constituents (magnesium, citric acid, and osteopontin) influence the formation, stability of calcium phosphate. These principles are also applied to pathological calcification such as renal stone formation. A similar approach is used as the author discussed optic calcification on implanted intraocular lens (IOL) surfaces and the roles that viscoelastic materials play during surgery.

Xiangying Guan, PhD. Studied biomineralization / demineralziation at State University of New York (SUNY)at Buffalo. Research fellow at Thomas Jefferson University College of Medicine, Philadelphia.