LCMS/MS Method for the Estimation of Montelukast in Human Plasma: Developed and Validated according to FDA guidelines

Liquid chromatography-tandem mass spectrometry (LCMS/MS) is one of the most advanced techniques in the development of Methods for estimation of drugs in biological fluids. The current work includes basic techniques in Liquid Chromatography, Mass Spectrometry, Sample Preparation in bioanalyses, development of bioanalytical method for the quantitative estimation of Montelukast in human plasma and validating it according to FDA guidelines. The method finds its application in biequivalence studies of Montelukast, a cysteinyl leukotriene receptor antagonist used in the treatment of asthma and other allergic conditions.

Dr. Bilal has been working in the field of Pharmaceutical Analysis from the past 5 years. He has developed many methods for the estimation of drugs in human plasma using HPLC and LCMS/MS techniques. He is presently working on chromatographic separation of bioactive molecules from Himalayan Medicinal plants for the treatment of hyperlipidemia.