Large-Scale Optimization with Applications: Part III: Molecular Structure and Optimization (The IMA Volumes in Mathematics and its Applications) Part III: Molecular Structure and Optimization

Biegler, Lorenz T., Thomas Coleman and Andrew R. Conn

ISBN 10: 0387982884 / ISBN 13: 9780387982885

Published by Springer 11.09.1997., 1997

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207 Seiten Exemplar aus einer wissenchaftlichen Bibliothek Sprache: Englisch Gewicht in Gramm: 469 23,6 x 15,5 x 1,8 cm, Gebundene Ausgabe. Seller Inventory # 384478

Bibliographic Details

Title: Large-Scale Optimization with Applications: ...

Publisher: Springer 11.09.1997.

Publication Date: 1997

Binding: Hardcover

Condition: Sehr gut

Edition: Auflage: 1997.

About this title

Synopsis:

Many important molecular conformation problems, such as protein folding, are expressed as global minimization problems. It is the fact that local minimization is insufficient, that markedly differentiates this volume from the previous two. Unfortunately, global minimization problems that result from models of molecular conformation are usually intractable. For example, simple 1-dimensional versions of distance conformation problems are NP-hard. Nevertheless, there has been significant recent progress in the design of promising heuristic strategies (often involving the use of high- performance parallel computers) for computing approximate global minimizers. The purpose of the sessions represented in this volume was to discuss the new algorithmic advances for global minimization in the context of protein folding and related molecular minimization problems. Emphasis was on practical shortcomings of current approaches, outstanding problems and questions, and the use of high-performance parallel computers.