Development of computational methodologies for processing of microscopic images is a new health-physical method. It is laser polarimetry of biological tissues histological sections. It is based on measurement of the coordinate distributions (polarization maps) in the plane of polarization states of histological sections microscopic images of biological tissues. This method allows a new, inaccessible to the histological and mathematical methods of analysis, information on the optical anisotropy (linear and circular birefringence) multiscale structural elements of different biological objects. At the same time, a complex analysis of the polarization maps of a tissue specimen is azimuthally dependent to the probing beam polarization plane and sample rotation angle. This makes it difficult to use this method in comparative research groups histological sections with different pathologies. Thus, further progress of laser polarimetry may be connected with the development of azimuthally stable methods of direct measurement of the parameters of linear and circular birefringence.

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