Learning and Inference in Computational Systems Biology

Sanguinetti Guido Rattray Magnus Girolami Mark Lawrence Neil D.

ISBN 10: 026201386X / ISBN 13: 9780262013864

Published by The MIT Press Bookstore, 2009

About this Item

pp. viii + 362.

Seller Inventory # 18693529

Bibliographic Details

• Title: Learning and Inference in Computational Systems Biology
• Publisher: The MIT Press Bookstore
• Publication Date: 2009
• Language: English
• ISBN 10: 026201386X
• ISBN 13: 9780262013864
• Binding: Hardcover
• Condition: Used

About this title

Synopsis

Tools and techniques for biological inference problems at scales ranging from genome-wide to pathway-specific.

Computational systems biology unifies the mechanistic approach of systems biology with the data-driven approach of computational biology. Computational systems biology aims to develop algorithms that uncover the structure and parameterization of the underlying mechanistic modelin other words, to answer specific questions about the underlying mechanisms of a biological systemin a process that can be thought of as learning or inference. This volume offers state-of-the-art perspectives from computational biology, statistics, modeling, and machine learning on new methodologies for learning and inference in biological networks.The chapters offer practical approaches to biological inference problems ranging from genome-wide inference of genetic regulation to pathway-specific studies. Both deterministic models (based on ordinary differential equations) and stochastic models (which anticipate the increasing availability of data from small populations of cells) are considered. Several chapters emphasize Bayesian inference, so the editors have included an introduction to the philosophy of the Bayesian approach and an overview of current work on Bayesian inference. Taken together, the methods discussed by the experts in Learning and Inference in Computational Systems Biology provide a foundation upon which the next decade of research in systems biology can be built. Florence d'Alch e-Buc, John Angus, Matthew J. Beal, Nicholas Brunel, Ben Calderhead, Pei Gao, Mark Girolami, Andrew Golightly, Dirk Husmeier, Johannes Jaeger, Neil D. Lawrence, Juan Li, Kuang Lin, Pedro Mendes, Nicholas A. M. Monk, Eric Mjolsness, Manfred Opper, Claudia Rangel, Magnus Rattray, Andreas Ruttor, Guido Sanguinetti, Michalis Titsias, Vladislav Vyshemirsky, David L. Wild, Darren Wilkinson, Guy Yosiphon

About the Author

Magnus Rattray is Senior Lecturer and Member of the Machine Learning and Optimisation Research Group in the School of Computer Science at the University of Manchester.