Lectin Conjugated Gastro-Retentive Delivery System | Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori | Sunil K. Jain (u. a.) | Taschenbuch | Englisch | LAP Lambert Academic Publishing | EAN 9783659213779 | Verantwortliche Person f�r die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabr�ck, mail[at]preigu[dot]de | Anbieter: preigu.

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Bibliographic Details

Title

Lectin Conjugated Gastro-Retentive Delivery System | Gastro-Retentive Multiparticulate Delivery System of Clarithromycin for the Effective Treatment of Helicobacter Pylori

Publisher

LAP Lambert Academic Publishing

Publication Date

2012

Language

English

ISBN 10

3659213772

ISBN 13

9783659213779

Binding

Taschenbuch

Condition

Neu

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About this title

Synopsis

An optimized Ethylcellulose microspheres of Clarithromycin were successfully prepared using emulsion/ solvent evaporation method and Con-A was successfully attached to the microspheres using carbodiimide method. Attachment of lectin to the Ethylcellulose microspheres significantly increased the mucoadhesiveness and also controls the release of Clarithromycin in simulated GI fluids. Conjugation aggregation assay suggesting that the lectin can be able to target in the treatment of Helicobacter pylori infection in peptic ulcer disease. Gamma scintigraphy study suggesting that Con-A lectin conjugated Ethylcellulose microspheres have gained considerable attention due to their ability to adhere to the mucus layer, as well as to release the drug in a controlled manner. It is concluded that designed targeted delivery system could possibly increases the bioavailability of Clarithromycin and treated the gastric ulcer in an effective manner.

About the Author

Dr. SUNIL K. JAIN, Assistant Professor (Pharmaceutics), SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur, INDIA

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