Editor(s): Sillence, Dan. Num Pages: 225 pages, illustrations (black and white, and colour). BIC Classification: PSBH. Category: (P) Professional & Vocational. Dimension: 238 x 156 x 19. Weight in Grams: 514. . 2013. Hardcover. . . . .

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Bibliographic Details

Title: Lipid Rafts: Properties, Controversies and Roles in Signal Transduction (Cell Biology Research Progress)
Publisher: Nova Science Pub Inc
Publication Date: 2013
Language: English
ISBN 10: 1629489611
ISBN 13: 9781629489612
Binding: Hardcover
Condition: New

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Synopsis

For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells is not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organisation of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer -- 'lipid raft' hypothesis. Lipid rafts are compelling since they provide spontaneous organisation for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains Do they rely on specific interactions and how do they change in response to cell signalling processes Do they help in the understanding of cell signalling and immune function and how may they be disrupted in disease processes such as neurodegeneration

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