Lipids and Drug Resistance in Fungi: A Study

Ritu Pasrija

ISBN 10: 3659855871 / ISBN 13: 9783659855870

Published by LAP LAMBERT Academic Publishing, 2016

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - Candida albicans is an opportunistic diploid fungus that causes infection in immunocompromised and debilitated patients. Wide spread and prolonged usage of azoles in recent years has led to the rapid development of the phenomenon of azole resistance which poses a major threat to antifungal therapy. Various mechanisms contribute towards the development of resistance in Candida such as overexpression of pumps encoded by genes belonging to ATP-Binding Cassette (ABC) and Major Facilitator Superfamilies of transporters (MFS), and/or mutations in the target enzyme of azoles etc. Based on several studies, a close interaction between membrane lipids and drug extrusion pump proteins has been realized. It has been shown that the action of antifungals is modulated by subtle modification of the membrane lipid composition.

Seller Inventory # 9783659855870

Bibliographic Details

• Title: Lipids and Drug Resistance in Fungi: A Study
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2016
• Language: English
• ISBN 10: 3659855871
• ISBN 13: 9783659855870
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 9D millimeters 220 millimeters width by 150 millimeters height by 9 millimeters depth
• Weight: 238 grams

About this title

Synopsis

Candida albicans is an opportunistic diploid fungus that causes infection in immunocompromised and debilitated patients. Wide spread and prolonged usage of azoles in recent years has led to the rapid development of the phenomenon of azole resistance which poses a major threat to antifungal therapy. Various mechanisms contribute towards the development of resistance in Candida such as overexpression of pumps encoded by genes belonging to ATP-Binding Cassette (ABC) and Major Facilitator Superfamilies of transporters (MFS), and/or mutations in the target enzyme of azoles etc. Based on several studies, a close interaction between membrane lipids and drug extrusion pump proteins has been realized. It has been shown that the action of antifungals is modulated by subtle modification of the membrane lipid composition.

About the Author

Dr Ritu Pasrija is an Assistant Professor in the Biochemistry Department of Maharshi Dayanand University in Rohtak, Haryana.She has an experience of 14 years in teaching & research. She did her doctoral studies from Jawaharlal Nehru University, New Delhi. She was recipient of Research Fellowship from CSIR and published several international papers