This book presents an overview of lysosomal storage disorders, and provides the reader with an understanding of clinical features, associated complications, and diagnosis and management approaches. It also describes historical developments in the field and current thinking relating to pathophysiology and prospective therapeutic strategies.The book is written by an expert in the field who has been engaged in both basic and clinical research, in addition to having extensive practical experience in patient care. It is written from the perspective of someone who entered the field just as treatment was being introduced, and who has been engaged in the seminal clinical trials and the development of therapeutic guidelines. It offers a broad perspective and should appeal to both novices and experts in the field who seek a single resource that provides a comprehensive picture of relevant topics on this subject.A multi-faceted volume, the author addresses the issue of diagnosis and patient management, underlying mechanisms of disease, sources of morbidity and treatment options, covering issues of interest to both the basic scientist and the clinician.

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The content is generally well-balanced and provides an accurate overview of a rapidly advancing field of medicine ... This book provides an extraordinarily comprehensive, though concise and readable, review of the subject, by an acknowledged expert in the area. It fills a very important gap in the general medical literature and deserves a place on the bookshelf of general physicians everywhere. --Joe T R Clarke, Professor, MD, PhD, FRCPC, University of Toronto, Canada

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