Malaria Vaccine Development : A Recombinant BCG-Based Vaccine Expressing Blood-Stage Antigen of P. Falciparum

Language: English

Published by LAP LAMBERT Academic Publishing, 2011

384430486X / 9783844304862

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nach der Bestellung gedruckt Neuware - Printed after ordering - Vaccine development against blood-stage antigens is aimed at inducing inhibitory antibodies towards the circulating merozoites, thus preventing them from infecting red blood cells. One such blood stage candidate is the 19 kDa C-terminus of merozoite surface protein-1 (MSP-1C). MSP-1C has been shown to induce both inhibitory as well as blocking antibodies, the latter blocking the protective effects of the former. Inhibitory antibodies will bind to MSP-1C and inhibit merozoite invasion of red blood cell but the binding of blocking antibodies can prevent binding of inhibitory antibodies thereby allowing the parasite to invade an erythrocyte. This book provides some information regarding the development of blood-stage malaria vaccine based on mutated version of MSP-1C which induces inhibitory antibodies against malarial parasite. The use of live recombinant Mycobacterium bovis bacille Calmette Guerin as a vaccine vehicle was also described in this book. The rBCG expressing the mutated version of MSP-1C was found to induce some level of protections against P. falciparum; thus paving the way for the rational use of rBCG as a blood-stage malaria vaccine candidate.…

Seller Inventory # 9783844304862

Title
Malaria Vaccine Development : A Recombinant BCG-Based Vaccine Expressing Blood-Stage Antigen of P. Falciparum
Author
Nurul Asma Abdullah
Publisher
LAP LAMBERT Academic Publishing
Publication year
2011
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
384430486X
ISBN 13
9783844304862
Item weight
286 grams
Dimensions
220x150x12 mm

AHA-BUCH GmbH

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