The Mammary Gland as an Experimental Model (Cold Spring Harbor Perspectives in Biology)

Mina Bissell

ISBN 10: 087969906X / ISBN 13: 9780879699062

Published by Cold Spring Harbor Perspective, 2011

About this Item

Gebraucht - Wie neu -Studies of mammary gland biology are critically important given the prevalence of breast cancer. This organ represents an excellent model system for research into developmental mechanisms, gene regulation, tissue organization, hormonal action, secretion, and stem cell biology. This book provides valuable lessons for all cell, developmental, and cancer biologists.

Seller Inventory # 43299

Bibliographic Details

• Title: The Mammary Gland as an Experimental Model (Cold Spring Harbor Perspectives in Biology)
• Publisher: Cold Spring Harbor Perspective
• Publication Date: 2011
• Language: English
• ISBN 10: 087969906X
• ISBN 13: 9780879699062
• Binding: Gebundene Ausgabe
• Condition: Wie neu
• Dimensions: 25.9W x 18.3H x 2.3D centimeters 25.9 centimeters width by 18.3 centimeters height by 2.3 centimeters depth
• Weight: 878 grams

About this title

Synopsis

Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis processes during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate. The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three dimensional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology, as well as those focused specifically on mammary gland biology and breast cancer.

About the Author

Mina J. Bissell is at the Lawrence Berkeley National Laboratory; Kornelia Polyak is at Harvard Medical School; Jeffrey M. Rosen is at the Baylor College of Medicine. All three editors are famous cancer researchers.