Mass Spectrometric Studies of Bioactive Constituents in Adhatoda Spp.: Studies of bioactive constituents in Adhatoda species

Kumar, Brijesh/ Singh, Awantika/ Madhusudanan, K. P.

ISBN 10: 6202007737 / ISBN 13: 9786202007733

Published by LAP LAMBERT Academic Publishing, 2017

About this Item

60 pages. 8.66x5.91x0.14 inches. In Stock.

Seller Inventory # zk6202007737

Bibliographic Details

• Title: Mass Spectrometric Studies of Bioactive Constituents in Adhatoda Spp.: Studies of bioactive constituents in Adhatoda species
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2017
• Language: English
• ISBN 10: 6202007737
• ISBN 13: 9786202007733
• Binding: Paperback
• Condition: Brand New
• Weight: 0.14 kilograms

About this title

Synopsis

Adhatoda beddomei and Adhatoda vasica are popular Ayurvedic medicinal plants in India, belonging to the family Acanthaceae. Tricyclic quinazoline alkaloids, abundantly present in adhatoda, are found to be responsible for the broad-spectrum medicinal properties. The other major class of compounds found in adhatoda is the flavonoids. The project initiated by us aims to seek identification and characterization of the alkaloids and flavonoids based on their fragmentation patterns. Methods were also developed and validated to quantify the major alkaloid and flavonoid components simultaneously. The developed method was successfully applied to quantify the phytoconstituents in adhatoda herbal formulations available in the market. The ethanol extracts of the samples collected from Palode, Kerala, India were subjected to LC-MS/MS analyses after selective extraction of the alkaloid and flavonoid fractions under positive and negative ion conditions, respectively. Among the 23 alkaloids tentatively identified, 16 have been previously reported in Adhatoda species. 29 flavonoids were tentatively identified, including 17 C-, nine O-glycosides and three flavonoids from the LC-MS/MS spectra.

About the Author

Dr. Brijesh Kumar is senior principal scientist and facility in charge SAIF, CSIR-CDRI, Lucknow, India. He has more than 120 publications. Dr. Awantika Singh has completed her PhD under supervision of Dr. Brijesh Kumar. Dr. K. P. Madhusudanan is superannuated from CSIR-CDRI as chief scientist and contributed more than 150 publications.