Mechanical Forces: Their Effects on Cells and Tissues (Biotechnology Intelligence Unit)

Gooch, Keith J.; Tennant, Christopher J.

ISBN 10: 3540629289 / ISBN 13: 9783540629283

Published by Springer, 1997

About this Item

A copy that has been read, remains in good condition. All pages are intact, and the cover is intact. The spine and cover show signs of wear. Pages can include notes and highlighting and show signs of wear, and the copy can include "From the library of" labels or previous owner inscriptions. 100% GUARANTEE! Shipped with delivery confirmation, if you're not satisfied with purchase please return item! Ships via media mail.

Seller Inventory # OTV.3540629289.G

Bibliographic Details

• Title: Mechanical Forces: Their Effects on Cells and Tissues (Biotechnology Intelligence Unit)
• Publisher: Springer
• Publication Date: 1997
• Language: English
• ISBN 10: 3540629289
• ISBN 13: 9783540629283
• Binding: Hardcover
• Condition: good

About this title

Synopsis

Animal Cell Culture nimal cell culture began in 1912 when Alexis Carrel grew bits of chick heart A in vitro by placing them into a drop of horse plasma. When the plasma clotted, it formed a solid surface into which the heart cells explanted. Left unattended, these cells died within several days. By regularly feeding the grow­ ing cells with aqueous extracts of whole chick embryos and periodically sub­ dividing them, Carrel was able to maintain the cells for extended periods. From these initial experiments, cell culture has expanded into an important component of biological research and commercial production. Animal cell culture is an important tool for the study of complex biologi­ cal systems. In vivo it is often impossible to target a treatment to one specific cell type or to adequately control the environment. For example, it is impos­ sible to selectively depolarize endothelial cells in vivo to determine the role of transmembrane potential in the transduction of fluid mechanical forces generated by blood flow to a biochemical response. Depolarizing all of the cells within the vascular system by injecting potassium chloride into the animal's bloodstream clearly is not an option, as it will lead to cardiac arrest.