Mechanisms of DNA Damage and Repair

Michael G. Simic

ISBN 10: 1461594642 / ISBN 13: 9781461594642

Published by Springer, Springer US Dez 2012, 2012

About this Item

This item is printed on demand - Print on Demand Titel. Neuware -This book is based on the papers presented at the conference on 'Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment,' held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 596 pp. Englisch.

Seller Inventory # 9781461594642

Bibliographic Details

• Title: Mechanisms of DNA Damage and Repair
• Publisher: Springer, Springer US Dez 2012
• Publication Date: 2012
• Language: English
• ISBN 10: 1461594642
• ISBN 13: 9781461594642
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 254W x 178H x 32D millimeters 254 millimeters width by 178 millimeters height by 32 millimeters depth
• Weight: 1105 grams

About this title

Synopsis

This book is based on the papers presented at the conference on "Mecha­ nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.