Mechanisms of Leptin in Breast Cancer Development and Progression | Profiling of Leptin Regulated Gene and Protein Expression in Human Breast Cancer Cells

Candida Perera (u. a.)

ISBN 10: 3838373332 / ISBN 13: 9783838373331

Published by LAP LAMBERT Academic Publishing, 2010

About this Item

Mechanisms of Leptin in Breast Cancer Development and Progression | Profiling of Leptin Regulated Gene and Protein Expression in Human Breast Cancer Cells | Candida Perera (u. a.) | Taschenbuch | 128 S. | Englisch | 2010 | LAP LAMBERT Academic Publishing | EAN 9783838373331 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.

Seller Inventory # 107437704

Bibliographic Details

• Title: Mechanisms of Leptin in Breast Cancer Development and Progression | Profiling of Leptin Regulated Gene and Protein Expression in Human Breast Cancer Cells
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2010
• Language: English
• ISBN 10: 3838373332
• ISBN 13: 9783838373331
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 9D millimeters 220 millimeters width by 150 millimeters height by 9 millimeters depth
• Weight: 209 grams
• Seller catalogs:
  • Bücher

About this title

Synopsis

Obesity is a recently established risk factor for breast cancer. A characteristic of obesity is elevated circulating levels of adipocyte-derived hormone leptin. Evidence indicates leptin plays an important role in breast cancer development and progression; however the mechanisms involved are poorly understood. Towards better defining the role of leptin in breast cancer, herein we describe the identification of leptin-regulated genes and proteins in hormone responsive MCF-7 human breast cancer cells. Leptin significantly increased the proliferation and protein secretion in MCF-7 cells. The effect of leptin in modulating the extracellular environment and inhibiting apoptosis was also determined. These data suggest leptin regulates mammary tumor cell behavior through multiple mechanisms. In addition to regulating mitogenic cell signaling pathways, leptin influences mammary tumor cell growth by regulating apoptosis, cell cycle, secretion of autocrine/ paracrine factors and modulating the extracellular environment. Identification of leptin-regulated factors provides valuable mechanistic links into the relationship between obesity and breast cancer.

About the Author

Dr Candida Perera received her doctorate in cancer biology from Purdue University. Presently she works as a Scientist conducting research in cancer drug discovery and development. Dr Ignacio Camarillo received his doctorate from Wayne State University, and holds a faculty position in the Department of Biology, Purdue University.