Mechanisms of Lymphocyte Activation and Immune Regulation: Mechanisms of Lymphocyte Activation and Immune Regulation Vol 213 (Advances in Experimental Medicine and Biology)

Gupta, Sudhir; Paul, William E.; Fauci, Anthony

ISBN 10: 0306425688 / ISBN 13: 9780306425684

Published by Kluwer Academic / Plenum Publishers, 1987

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348 Seiten ex Library Book aus einer wissentschaftlichen Bibliothek Sprache: Englisch Gewicht in Gramm: 550.

Seller Inventory # 236570

Bibliographic Details

• Title: Mechanisms of Lymphocyte Activation and Immune Regulation: Mechanisms of Lymphocyte Activation and Immune Regulation Vol 213 (Advances in Experimental Medicine and Biology)
• Publisher: Kluwer Academic / Plenum Publishers
• Publication Date: 1987
• Language: English
• ISBN 10: 0306425688
• ISBN 13: 9780306425684
• Binding: Gebundene Ausgabe
• Condition: Gut
• Weight: 550 grams
• Seller catalogs:
  • Alle Bücher

About this title

Synopsis

During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.