Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS : Dissolution media with colonic probiotics

Niranjan Goud Kotla

ISBN 10: 3848482878 / ISBN 13: 9783848482870

Published by LAP LAMBERT Academic Publishing, 2014

About this Item

nach der Bestellung gedruckt Neuware - Printed after ordering - Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade 'A' honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery.

Seller Inventory # 9783848482870

Bibliographic Details

• Title: Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS : Dissolution media with colonic probiotics
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2014
• Language: English
• ISBN 10: 3848482878
• ISBN 13: 9783848482870
• Binding: Taschenbuch
• Condition: Neu
• Dimensions: 220W x 150H x 7D millimeters 220 millimeters width by 150 millimeters height by 7 millimeters depth
• Weight: 161 grams

About this title

Synopsis

Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade “A” honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery.

About the Author

Niranjan Goud Kotla,research scholar in pharmaceutical segment, completed B. Pharmacy from Osmania University, Hyderabad and M. Pharmacy from LPU, Punjab. My vital area of research is targeted drug delivery, dissolution methodologies and formulation development.Filled 2 patents and published my papers in international journals and in Elsevier.