Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS

Language: English

Published by LAP LAMBERT Academic Publishing Feb 2014, 2014

3848482878 / 9783848482870

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This item is printed on demand - Print on Demand Titel. Neuware -Till date, pursuit for cost effective and animal sparing colon specific bio-relevant dissolution media has been a foremost challenge facing pharmaceutical scientists over many decades.It is problematic to mimic the dynamic and ecologically diverse features of the colon in dissolution vessel.With the knowledge of enormous colonic microflora, the predominant species Bacteroides, Bifidobacterium, Eubacterium, Streptococcus and Lactobacillus species were cultured in 12% w/v skimmed milk powder and 5%w/v grade 'A' honey. Probiotic culture was added to the dissolution media in order to test the drug release of polysaccharide based formulations. USP dissolution apparatus I/II with gradient pH dissolution method were used to evaluate the drug release from formulations meant for colonic drug delivery. Drug release from 5-fluorouracil granules and metronidazole tablets were assed under gastric, small intestine conditions and also within a simulated colonic environment involving existing rat caecal, human fecal media and compared with novel probiotic media. The present method can be successfully applied for the drug release testing of any oral formulations meant for colonic delivery.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 96 pp. Englisch.

Seller Inventory # 9783848482870

Title
Media for in Vitro Dissolution Testing of Polysaccharide Based CDDS
Author
Niranjan Goud Kotla
Publisher
LAP LAMBERT Academic Publishing Feb 2014
Publication year
2014
Condition
Neu
Dust jacket
Dust Jacket Included
Binding
Taschenbuch
Language
English
ISBN 10
3848482878
ISBN 13
9783848482870
Item weight
161 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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