Memory cells in diabetes: The effect of hyperglycemic memory on T- cells function

Salman, Mohammed Ali, Sultan, Baqur A., AL-Mosawi, Jaafar k.

ISBN 10: 3848490757 / ISBN 13: 9783848490752

Published by LAP LAMBERT Academic Publishing, 2012

About this Item

LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS.

Seller Inventory # ERICA79638484907576

Bibliographic Details

• Title: Memory cells in diabetes: The effect of hyperglycemic memory on T- cells function
• Publisher: LAP LAMBERT Academic Publishing
• Publication Date: 2012
• Language: English
• ISBN 10: 3848490757
• ISBN 13: 9783848490752
• Binding: Paperback
• Condition: Like New
• Book Type: book

About this title

Synopsis

Antigen exposure is a strong stimulator of lymphocytes that triggers a variety of events including formation of cytokines such as interferon (IFN)-gamma (Cantrell, 1996), the defense against pathogen is impaired at high ambient osmolarity such as in the hyperosmolar renal medulla. Moreover, the immune response was reported to be impaired in diabetes Mellitus, which typically leads to increase of extracellular osmolarity,It cannot be excluded that "hyperglycemic memory" confounds the relationship between cell function and concomitant blood glucose concentration, i.e., hyperglycemia-induced changes in gene expression and biological reactions such as advanced glycation-end products in long-lived macromolecules may not be reversed when glycemia returns to normal, so that poor control is progressively "imprinted" on the cells , resulting in impairment of cellular immune activity.

About the Author

Dr.Mohammed Ali S. Al-Kaaby,MBCHB(MD),MSc.Clinical Immunology/department of Pathology and Foreinsic Medicine/Medical college/Wasit University,Iraq.graduated from Medical College al-kufa Un.in 2003/iraq,finished Masterdegree in Medical Microbiology/Clinical Immunology in 2010 same collegeteaching in Medical College/Wasit Un/Iraq.preparing my PHd