Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis
For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments.
Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future.
Beginning with overviews, Metabolism and Bacterial Pathogenesis covers
- a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations
- intracellular, respiratory, and enteric pathogens
- pathogen-specific nutrient acquisition in hosts
- mechanisms of host-driven metabolic adaptation by pathogens
- metabolic regulation of virulence gene expression
Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.
Tyrrell was born in Bartlesville, Oklahoma, and is married for 29 years to Sharri Conway, an elementary school teacher. They have two children. Tyrrell graduated from Oklahoma State University with a doctorate in Microbiology. He held faculty appointments at the University of Florida, University of Nebraska, Ohio State University, the University of Oklahoma, and currently is Professor and Head of Department of Microbiology and Molecular Genetics at Oklahoma State University. Amongst several scientific discoveries Tyrrell is the co-inventor of U.S. Patent number 5,000,000 for genetically engineering E. coli to make biofuels and published the first DNA microarray paper on E. coli. He and Paul Cohen were the first scientists to systematically determine what carbon sources are used by E. coli to colonize the animal intestine. Tyrrell is a member of the American Academy of Microbiology. If he had time, he would read more novels and go fishing more often.
