Le metastasi derivano dai tumori solidi quando le cellule cancerose subiscono cambiamenti e progrediscono attraverso una cascata che crea tumori disseminati. Le metastasi sono considerate tumori secondari derivati da un tumore primario. Il destino delle cellule carcinomatose disseminate � influenzato dall'interazione durante il transito nel sistema circolatorio. Il sistema immunitario pu� sia promuovere che inibire le metastasi ed � importante conoscere i mediatori coinvolti e il modo in cui esercitano il loro effetto, al fine di identificare nuovi bersagli per prevenire la malattia metastatica.

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