Title: Method Validation and Stability Analysis of Rifampicin by LC and LC-MS : Stability Studies of Rifampicin: Method Validation, and Characterization of Degradation Products by LC and LC-MS.
Publisher: LAP LAMBERT Academic Publishing
Publication Date: 2025
Language: English
ISBN 10: 6202433051
ISBN 13: 9786202433051
Binding: Taschenbuch
Condition: Neu
Dimensions: 220 millimeters width by 150 millimeters height by 7 millimeters depth
Weight: 173 grams

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This book presents a comprehensive study on the stability of rifampicin, a first-line anti-tuberculosis drug, through method development, validation, and characterization of its degradation products. It begins with an overview of tuberculosis, rifampicin's pharmacological profile, and the importance of stability-indicating methods in pharmaceutical quality control. Using HPLC and LC-MS techniques, the study optimizes chromatographic conditions and develops a validated stability-indicating method as per ICH guidelines. Forced degradation experiments under acidic, alkaline, oxidative, photolytic, and thermal stress reveal rifampicin's susceptibility to hydrolysis and other degradative pathways, with detailed characterization of degradation products. The validated method demonstrated accuracy, precision, linearity, robustness, and suitability for analyzing rifampicin in bulk and dosage forms. The work highlights the scientific and regulatory significance of stability testing in ensuring drug safety, efficacy, and quality throughout its shelf life, offering valuable insights for pharmaceutical research and development.

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