Method Validation and Stability Analysis of Rifampicin by LC and LC-MS

Language: English

Published by LAP LAMBERT Academic Publishing Sep 2025, 2025

6202433051 / 9786202433051

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This item is printed on demand - Print on Demand Titel. Neuware -This book presents a comprehensive study on the stability of rifampicin, a first-line anti-tuberculosis drug, through method development, validation, and characterization of its degradation products. It begins with an overview of tuberculosis, rifampicin's pharmacological profile, and the importance of stability-indicating methods in pharmaceutical quality control. Using HPLC and LC-MS techniques, the study optimizes chromatographic conditions and develops a validated stability-indicating method as per ICH guidelines. Forced degradation experiments under acidic, alkaline, oxidative, photolytic, and thermal stress reveal rifampicin's susceptibility to hydrolysis and other degradative pathways, with detailed characterization of degradation products. The validated method demonstrated accuracy, precision, linearity, robustness, and suitability for analyzing rifampicin in bulk and dosage forms. The work highlights the scientific and regulatory significance of stability testing in ensuring drug safety, efficacy, and quality throughout its shelf life, offering valuable insights for pharmaceutical research and development.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 104 pp. Englisch.

Seller Inventory # 9786202433051

Title
Method Validation and Stability Analysis of Rifampicin by LC and LC-MS
Author
Trupesh Pethani
Publisher
LAP LAMBERT Academic Publishing Sep 2025
Publication year
2025
Condition
Neu
Binding
Taschenbuch
Language
English
ISBN 10
6202433051
ISBN 13
9786202433051
Item weight
173 grams
Dimensions
220x150x7 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germany

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Impressum Thorsten Retsch Buchversand Mimpf2000 Oberölschnitz 16 95517 Emtmannsberg Deutschland Telefon: 09209-2023188 Email: mimpf2000@online.de USt-ID-Nr.: DE 235096871 Wir führen gebrauchte Bücher aus allen Sparten der Literatur

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