Methods in Cell Biology: Cilia: Model Organisms and Intraflagellar Transport: Vol 93
King, Stephen M. (Editor)
ISBN 10: 0123813778 ISBN 13: 9780123813770
Published by Academic Pr, 2009
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1st edition. 416 pages. 9.25x7.50x0.75 inches. In Stock. Seller Inventory # __0123813778
Synopsis:
Cilia are highly conserved organelles that serve motile functions, sensory functions, or both. These organelles power cell movement, generate fluid flow in various organs, act as sensors of the extracellular environment and have been modified for various specialized tasks such as light reception and smell. Defects in these ubiquitous organelles lead to a broad array of human genetic disorders that range from polycystic kidney disease, retinal degeneration, epilepsy and infertility to developmental defects such as situs inversus and polydactyly. This volume is the third in a three-part series on cilia that focuses on the use of model organisms to gain insight into ciliary function and on the process of intraflagellar transport that is essential for the assembly and maintenance of ciliary structures.
- Includes both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time
- Covers forward and reverse genetic analysis of IFT and biochemical methods to define the role of IFT components
- Methods presented cover molecular, genetic, and biochemical approaches to ciliary function in model organisms
About the Author: Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.
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Bibliographic Details
Title: Methods in Cell Biology: Cilia: Model ...
Publisher: Academic Pr
Publication Date: 2009
Binding: Hardcover
Condition: Brand New