Volume 459. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item,1300grams, ISBN:9780123745910.

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Bibliographic Details

Title

Methods in Enzymology: Complex Enzymes in Microbial Natural Product Biosynthesis, Part B (Volume 459)

Publisher

Academic Press

Publication Date

2009

Language

English

ISBN 10

0123745918

ISBN 13

9780123745910

Binding

Hardcover

Condition

Good

Weight

1300 grams

Seller catalogs

Biology

About this title

Synopsis

Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine.

Gathers tried and tested methods and techniques from top players in the field
Provides an extremely useful reference for the experienced research scientist
Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates

"About this title" may belong to another edition of this title.

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